structure activity relationships造句

• Structure activity relationships for these compounds have been proposed.
• The synthesis of JD-5037 and related analogs along with structure activity relationships has been reported.
• Various compound with similar structure activity relationships to cocaine that aren't technically analogues have been developed as well.
• In 1989 Martin helped to found the International Quantitative Structure Activity Relationship & Modeling Society ( now called the Cheminformatics and QSAR Society ).
• While many quantitative structure activity relationship analyses involve the interactions of a family of molecules with an enzyme or receptor binding site, QSAR can also be used to study the interactions between the structural domains of proteins.
• The octanol-water partition coefficient ( K ow ) is correlated with the potential for a chemical to bioaccumulate in organisms; the BCF can be predicted from log K ow, via computer programs based on structure activity relationship ( SAR ) or through the linear equation:
• Lately his efforts have focused primarily on the determination of quantitative structure activity relationships in both carcinogenic and chemotherapeutic agents, consisting of developing computer simulations of the actions of drugs, seeking correlations between the chemical structure of the drugs and their activity in order to produce better antitumor agents.
• Structure activity relationship ( SAR ) studies on myriocin homologs and partially synthetic derivatives showed that the configuration at the carbon bearing the 3-hydroxy group or the 14-ketone, the 6-double bond, and the 4-hydroxy group were not important for its activity and simplification of the structure of ISP-I was done in an attempt to reduce toxicity and improve drugability.
• Eritoran didn't performed well in phase III clinical trials, however it successfully treated cytokine storm in influenza animal models . [ 8 ] There were multiple factors that could be attributed to the failure of Eritoran against sepsis, which include poorly designed lipid A scaffold, antagonist designed using mice model where as it is known that there exists species differences ( human vs vice ) in lipid A recognition, role of MD2 / TLR4 PTMs on receptor function is not fully understood, recruitment of heterogenous patient population, and lack of a well-defined structure activity relationship ( SAR ) of LPS interaction with MD2 ( TLR4 ).